Dovitinib (TKI-258)
Product Specifications
CAS Number
405169-16-6
Synonyms
CHIR-258
Target
C-Kit
Applications
Protein Tyrosine Kinase
Smiles
CN1CCN (CC1) C2=CC3=C (C=C2) N=C (N3) C4=C (C5=C (C=CC=C5F) NC4=O) N
Molecular Formula
C21H21FN6O
Additionnal Information
Dovitinib (TKI258, CHIR258) is a multitargeted RTK inhibitor, mostly for class III (FLT3/c-Kit) with IC50 of 1 nM/2 nM, also potent to class IV (FGFR1/3) and class V (VEGFR1-4) RTKs with IC50 of 8-13 nM, less potent to InsR, EGFR, c-Met, EphA2, Tie2, IGF-1R and HER2 in cell-free assays. Phase 4.
Storage Conditions
2 years -80 in solvent
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