Cediranib (AZD2171)
Product Specifications
CAS Number
288383-20-0
Synonyms
NSC-732208
Target
VEGFR
Applications
Protein Tyrosine Kinase
Smiles
CC1=CC2=C (N1) C=CC (=C2F) OC3=NC=NC4=CC (=C (C=C43) OC) OCCCN5CCCC5
Molecular Formula
C25H27FN4O3
Additionnal Information
Cediranib (AZD2171, NSC-732208) is a highly potent VEGFR (KDR) inhibitor with IC50 of <1 nM, also inhibits Flt1/4 with IC50 of 5 nM/≤3 nM, similar activity against c-Kit and PDGFRβ, 36-, 110-fold and >1000-fold selective more for VEGFR than PDGFR-α, CSF-1R and Flt3 in HUVEC cells. Cediranib (AZD2171) induces autophagic vacuole accumulation. Phase 3.
Storage Conditions
2 years -80 in solvent
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