Bosutinib
Product Specifications
CAS Number
380843-75-4
Synonyms
SKI-606
Target
Src
Applications
Protein Tyrosine Kinase
Smiles
CN1CCN (CC1) CCCOC2=C (C=C3C (=C2) N=CC (=C3NC4=CC (=C (C=C4Cl) Cl) OC) C#N) OC
Molecular Formula
C26H29Cl2N5O3
Additionnal Information
Bosutinib is a novel, dual Src/Abl inhibitor with IC50 of 1.2 nM and 1 nM in cell-free assays, respectively. Bosutinib also effectively decreases the activity of PI3K/AKT/mTOR, MAPK/ERK and JAK/STAT3 signaling pathways by blocking the phosphorylation levels of p-ERK, p-S6, and p-STAT3. Bosutinib promotes autophagy.
Storage Conditions
2 years -80 in solvent
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