Afatinib
Product Specifications
CAS Number
850140-72-6
Synonyms
BIBW2992
Target
EGFR
Applications
Protein Tyrosine Kinase
Smiles
CN (C) CC=CC (=O) NC1=C (C=C2C (=C1) C (=NC=N2) NC3=CC (=C (C=C3) F) Cl) OC4CCOC4
Molecular Formula
C24H25ClFN5O3
Additionnal Information
Afatinib inhibits EGFR/ErbB irreversibly in vitro with IC50 of 0.5, 0.4, 10, 14, 1 nM for EGFRwt, EGFR L858R , EGFR L858R/T790M ErbB2 (HER2) and ErbB4 (HER4), respectively. Afatinib induces autophagy.
Storage Conditions
2 years -80 in solvent
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
MBS6471361-01 0.2 mL
CYP7A1, CT (Cholesterol 7-alpha-hydroxylase, Cholesterol 7-alpha-monooxygenase, CYPVII, Cytochrome P450 7A1, CYP7) (AP)
Sign In for Pricing
View Details MBS6471361-02 5x 0.2 mL
CYP7A1, CT (Cholesterol 7-alpha-hydroxylase, Cholesterol 7-alpha-monooxygenase, CYPVII, Cytochrome P450 7A1, CYP7) (AP)
Sign In for Pricing
View Details