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Afatinib

Product Specifications

CAS Number

850140-72-6

Synonyms

BIBW2992

Target

EGFR

Applications

Protein Tyrosine Kinase

Smiles

CN (C) CC=CC (=O) NC1=C (C=C2C (=C1) C (=NC=N2) NC3=CC (=C (C=C3) F) Cl) OC4CCOC4

Molecular Formula

C24H25ClFN5O3

Additionnal Information

Afatinib inhibits EGFR/ErbB irreversibly in vitro with IC50 of 0.5, 0.4, 10, 14, 1 nM for EGFRwt, EGFR L858R , EGFR L858R/T790M ErbB2 (HER2) and ErbB4 (HER4), respectively. Afatinib induces autophagy.

Storage Conditions

2 years -80 in solvent

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