ABT-737
Product Specifications
CAS Number
852808-04-9
Target
Bcl-2
Applications
Apoptosis
Smiles
CN (C) CCC (CSC1=CC=CC=C1) NC2=C (C=C (C=C2) S (=O) (=O) NC (=O) C3=CC=C (C=C3) N4CCN (CC4) CC5=CC=CC=C5C6=CC=C (C=C6) Cl) [N+] (=O) [O-]
Molecular Formula
C42H45ClN6O5S2
Additionnal Information
ABT-737 is a BH3 mimetic inhibitor of Bcl-xL, Bcl-2 and Bcl-w with EC50 of 78.7 nM, 30.3 nM and 197.8 nM in cell-free assays, respectively; no inhibition observed against Mcl-1, Bcl-B or Bfl-1. ABT-737 induces mitochondrial pathway apoptosis and mitophagy. Phase 2.
Storage Conditions
2 years -80 in solvent
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
CELCUFG022002S 40 Pieces/Case:2 Pieces/ PACKS:20 PACKS/CASE
2L, Seal Cap, Surface Treated,850cm2, Sterile
Sign In for Pricing
View Details 
129752-ML550 100 µL
MMP14 (Matrix Metalloproteinase-14, MMP-14, MMP-X1, Membrane-type Matrix Metalloproteinase 1, MT-MMP 1, MTMMP1, Membrane-type-1 Matrix Metalloproteinase, MT1-MMP, MT1MMP) (MaxLight 550)
Sign In for Pricing
View Details