Cucurbitacin IIb
Product Specifications
CAS Number
50298-90-3
Synonyms
CuIIb, Dihydrocucurbitacin F, 25-deacetyl hemslecin A
Target
STAT
Applications
Apoptosis
Smiles
CC1 (C (C (CC2C1=CCC3C2 (C (=O) CC4 (C3 (CC (C4C (C) (C (=O) CCC (C) (C) O) O) O) C) C) C) O) O) C
Molecular Formula
C30H48O7
Additionnal Information
Cucurbitacin IIb (CuIIb, Dihydrocucurbitacin F, 25-deacetyl hemslecin A) inhibits phosphorylation of STAT3, JNK and Erk1/2, enhances the phosphorylation of IκB and NF-κB, blocks nuclear translocation of NF-κB and decreases mRNA levels of IκBα and TNF-α. Cucurbitacin IIb exhibits anti-inflammatory activity and induces apoptosis. Cucurbitacin IIb is isolated from Hemsleya amabilis.
Storage Conditions
3 years -20°C powder
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