What is the catalog number for A-740003?

The catalog number for A-740003 is C07342-25mg.

What sizes are available for A-740003?

A-740003 is available in the following size(s): 25 mg.

Is A-740003 in stock?

A-740003 is currently made to order / not held in immediate stock. Contact us for lead time.

A-740003

Product Specifications

CAS Number

861393-28-4

Target

P2 Receptor

Applications

Neuronal Signaling

Smiles

CC (C) (C) C (NC (=O) CC1=CC (=C (C=C1) OC) OC) N=C (NC#N) NC2=CC=CC3=C2C=CC=N3

Molecular Formula

C26H30N6O3

Additionnal Information

A-740003 is a potent, selective and competitive antagonist of P2X7 receptor with IC50 of 18 nM and 40 nM for rat and human P2X7 receptors, respectively. A-740003 potently blocks agonist-evoked IL-1β release and pore formation with IC50 of 156 nM and 92 nM in differentiated human THP-1 cells.