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MAZ51

Product Specifications

CAS Number

163655-37-6

Target

VEGFR

Applications

Protein Tyrosine Kinase

Smiles

CN (C) C1=CC=C (C2=CC=CC=C21) C=C3C4=CC=CC=C4NC3=O

Molecular Formula

C21H18N2O

Additionnal Information

MAZ51 is a potent and selective inhibitor of vascular endothelial growth factor receptor (VEGFR) -3 (Flt-4) tyrosine kinase. MAZ51 induces cell rounding and G2/M cell cycle arrest in glioma cells through phosphorylation of Akt/GSK3β and activation of RhoA. MAZ51 inhibits the proliferation and induces the apoptosis of a variety of non-VEGFR-3-expressing tumor cell lines.

Storage Conditions

3 years -20°C powder

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