MAZ51
Product Specifications
CAS Number
163655-37-6
Target
VEGFR
Applications
Protein Tyrosine Kinase
Smiles
CN (C) C1=CC=C (C2=CC=CC=C21) C=C3C4=CC=CC=C4NC3=O
Molecular Formula
C21H18N2O
Additionnal Information
MAZ51 is a potent and selective inhibitor of vascular endothelial growth factor receptor (VEGFR) -3 (Flt-4) tyrosine kinase. MAZ51 induces cell rounding and G2/M cell cycle arrest in glioma cells through phosphorylation of Akt/GSK3β and activation of RhoA. MAZ51 inhibits the proliferation and induces the apoptosis of a variety of non-VEGFR-3-expressing tumor cell lines.
Storage Conditions
3 years -20°C powder
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