CS-2660 (JNJ-38158471)
Product Specifications
CAS Number
951151-97-6
Target
VEGFR
Applications
Protein Tyrosine Kinase
Smiles
CCNC (=O) NC1=C (C=C (C=C1) OC2=NC=NC (=C2C=NOC) N) Cl
Molecular Formula
C15H17ClN6O3
Additionnal Information
CS-2660 (JNJ-38158471) is a well tolerated, orally available, highly selective VEGFR-2 inhibitor with IC50 of 40 nM. CS-2660 (JNJ-38158471) also inhibits closely related tyrosine kinases such as RET (c-RET) and Kit (c-Kit) with IC50 of 180 nM and 500 nM, while it has no significant activity (>1 microM) against VEGFR-1 and VEGFR-3.
Storage Conditions
3 years -20°C powder
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