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GDC046

Product Specifications

CAS Number

1258292-64-6

Target

JAK

Applications

Angiogenesis

Smiles

C1CC1C (=O) NC2=NC=CC (=C2) NC (=O) C3=C (C=CC=C3Cl) Cl

Molecular Formula

C16H13Cl2N3O2

Additionnal Information

GDC046 (Compound 3) is a potent, selective, and orally bioavailable inhibitor of TYK2 with Ki of 4.8 nM, 83.8 nM, 27.6 nM and 253 nM for TYK2, JAK1, JAK2, and JAK3, respectively.

Storage Conditions

3 years -20°C powder

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TCF4 (Transcription Factor 4, TCF-4, Class B Basic Helix-loop-helix Protein 19, bHLHb19, Immunoglobulin Transcription Factor 2, ITF-2, SEF-2, SL3-3 Enhancer Factor 2, BHLHB19, ITF2, SEF2, MGC149723, MGC149724) (MaxLight 550)
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