Hispidol
Product Specifications
CAS Number
5786-54-9
Synonyms
(Z) -Hispidol
Target
TNF-alpha
Applications
Apoptosis
Smiles
C1=CC (=CC=C1C=C2C (=O) C3=C (O2) C=C (C=C3) O) O
Molecular Formula
C15H10O4
Additionnal Information
Hispidol is a potent inhibitor of TNF-α–induced monocyte adhesion to colon epithelial cells with an IC50 of 0.50 μM, and effectively suppresses LPS-induced TNF-α gene expression. Its inhibition of TNF-α is linked to reduced AP-1 transcriptional activity, highlighting its potential as a therapeutic candidate for IBD.
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