L 189
Product Specifications
CAS Number
64232-83-3
Target
DNA/RNA Synthesis
Applications
Cell Cycle
Smiles
C1=CC=C (C=C1) C=NC2=C (NC (=S) NC2=O) N
Molecular Formula
C11H10N4OS
Additionnal Information
L 189 is a novel human DNA ligase inhibitor with IC50 of 5 μM, 9 μM and 5 μM for hLigI, hLigIII and hLigIV, respectively. L 189 inhibits base excision repair (BER) and non-homologous end joining (NHEJ) . L 189 specifically sensitizes cancer cells to DNA damage.
Storage Conditions
3 years -20°C powder
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