(E/Z) -BCI
Product Specifications
CAS Number
15982-84-0
Synonyms
BCI, NSC 150117
Target
Phosphatase
Applications
Metabolism
Smiles
C1CCC (CC1) NC2C3=CC=CC=C3C (=O) C2=CC4=CC=CC=C4
Molecular Formula
C22H23NO
Additionnal Information
(E/Z) -BCI (BCI, NSC 150117) is an inhibitor of dual specific phosphatase 1/6 (DUSP1/DUSP6) and mitogen-activated protein kinase with EC50 of 13.3 μM and 8.0 μM for DUSP6 and DUSP1 in cells, respectively. (E) -BCI induces apoptosis via generation of reactive oxygen species (ROS) and activation of intrinsic mitochondrial pathway in H1299 lung cancer cells.
Storage Conditions
3 years -20°C powder
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