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(E/Z) -BCI

Product Specifications

CAS Number

15982-84-0

Synonyms

BCI, NSC 150117

Target

Phosphatase

Applications

Metabolism

Smiles

C1CCC (CC1) NC2C3=CC=CC=C3C (=O) C2=CC4=CC=CC=C4

Molecular Formula

C22H23NO

Additionnal Information

(E/Z) -BCI (BCI, NSC 150117) is an inhibitor of dual specific phosphatase 1/6 (DUSP1/DUSP6) and mitogen-activated protein kinase with EC50 of 13.3 μM and 8.0 μM for DUSP6 and DUSP1 in cells, respectively. (E) -BCI induces apoptosis via generation of reactive oxygen species (ROS) and activation of intrinsic mitochondrial pathway in H1299 lung cancer cells.

Storage Conditions

3 years -20°C powder

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