β-Amyloid (1-42), human

Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val-Ile-Ala

β-Amyloid (1-42), human is a peptide fragment composed of 42 amino acids, derived from amyloid precursor protein (APP), and plays a crucial role in Alzheimer's disease (AD) . It self-aggregates into oligomers and fibrils, with the oligomeric form being the most neurotoxic. These aggregates form amyloid plaques, a characteristic feature of AD, which interfere with cellular functions, cause mitochondrial dysfunction, and lead to neuronal cell death through oxidative stress, calcium dysregulation, and inflammation.