LDN-212320

LDN-212320 (LDN-0212320) is a glutamate transporter (GLT-1) /excitatory amino acid transporter 2 (EAAT2) activator (at translational level) . LDN-212320 (LDN-0212320) prevents nociceptive pain by upregulating astroglial GLT-1 expression in the hippocampus and ACC[1][2].

Product Specifications

CAS Number

[894002-50-7]

Product Name Alternative

LDN-0212320; OSU-0212320

UNSPSC

12352005

Hazard Statement

H302, H315, H319

Target

EAAT

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/LDN-212320.html

Concentration

10mM

Purity

98.92

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

CC1=CC=CC=C1CSC2=NN=C(C3=NC=CC=C3)C=C2

Molecular Formula

C17H15N3S

Molecular Weight

293.39

Precautions

H302, H315, H319

References & Citations

[1]Ghallab Alotaibi, et al. Effects of glial glutamate transporter activator in formalin-induced pain behaviour in mice. Eur J Pain. 2019 Apr;23 (4) :765-783.|[2]Xuechao Xing, et al. Structure-activity relationship study of pyridazine derivatives as glutamate transporter EAAT2 activators. Bioorg Med Chem Lett. 2011 Oct 1;21 (19) :5774-7.