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Z-Nle-Lys-Arg-AMC (acetate)

Product Specifications

UNSPSC Description

Z-Nle-Lys-Arg-AMC acetate is a fluorogenic peptide substrate that specifically monitors cathepsin B activity over a broad pH range[1].

Target Antigen

Cathepsin

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/z-nle-lys-arg-amc-acetate.html

Solubility

H2O : ≥ 100 mg/mL

Smiles

CCCC[C@@H](C(N[C@H](C(N[C@@H](CCCNC(N)=N)C(NC1=CC(O2)=C(C=C1)C(C)=CC2=O)=O)=O)CCCCN)=O)NC(OCC3=CC=CC=C3)=O.CC(O)=O.[x]

Molecular Weight

706.83 (free base)

References & Citations

[1]Yoon MC, et al. Distinct Cleavage Properties of Cathepsin B Compared to Cysteine Cathepsins Enable the Design and Validation of a Specific Substrate for Cathepsin B over a Broad pH Range. Biochemistry. 2023 Aug 1;62(15):2289-2300.

Shipping Conditions

Blue Ice

Product Datasheet

http://file.medchemexpress.com/batch_PDF/HY-155667A/Z-Nle-Lys-Arg-AMC-acetate-DataSheet-MedChemExpress.pdf

Product MSDS

http://file.medchemexpress.com/batch_PDF/HY-155667A/Z-Nle-Lys-Arg-AMC-acetate-SDS-MedChemExpress.pdf

Clinical Information

No Development Reported

Available Sizes

Curated Selection

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