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Z-Nle-Lys-Arg-AMC (acetate)

Z-Nle-Lys-Arg-AMC acetate is a fluorogenic peptide substrate that specifically monitors cathepsin B activity over a broad pH range[1].

Product Specifications

UNSPSC

12352211

Target

Cathepsin

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/z-nle-lys-arg-amc-acetate.html

Purity

99.58

Solubility

H2O : ≥ 100 mg/mL

Smiles

CCCC[C@@H](C(N[C@H](C(N[C@@H](CCCNC(N)=N)C(NC1=CC(O2)=C(C=C1)C(C)=CC2=O)=O)=O)CCCCN)=O)NC(OCC3=CC=CC=C3)=O.CC(O)=O.[x]

Molecular Formula

C36H50N8O7.xC2H4O2

Molecular Weight

706.83 (free base)

References & Citations

[1]Yoon MC, et al. Distinct Cleavage Properties of Cathepsin B Compared to Cysteine Cathepsins Enable the Design and Validation of a Specific Substrate for Cathepsin B over a Broad pH Range. Biochemistry. 2023 Aug 1;62 (15) :2289-2300.

Shipping Conditions

Blue Ice

Storage Conditions

-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture and light, under nitrogen)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

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