T6167923
Product Specifications
CAS Number
2437475-16-4
Target
MyD88
Applications
Immunology & Inflammation
Smiles
BrC1=CC (S (=O) (N2CCN (C (N[C@H] (C3=CC=CS3) C) =O) CC2) =O) =CC=C1
Molecular Formula
C17H20BrN3O3S2
Additionnal Information
T6167923 is a selective MyD88-dependent signaling pathway inhibitor that directly interacts with the Toll/IL-1 receptor (TIR) domain of MyD88, preventing its homodimerization. This compound demonstrates inhibitory effects on NF-κB-mediated Staphylococcus enterotoxin AP (SEAP) activity and exhibits anti-inflammatory properties, with IC50 values of 2.7 μM (IFN-γ), 2.9 μM (IL-1β), 2.66 μM (IL-6), and 2.66 μM (TNF-α) .
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