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GDC-2992

Product Specifications

CAS Number

2753651-10-2

Synonyms

RO7656594

Target

Androgen Receptor

Applications

Endocrinology & Hormones

Molecular Formula

C45H51ClN8O5

Additionnal Information

GDC-2992 (RO7656594, Compound 28A) is an orally active degrader of androgen receptor (AR) with a DC50 of 2.7 nM. It binds to AR and cereblon (CRBN), inducing AR ubiquitination and degradation. GDC-2992 also inhibits cell proliferation in VCaP cells and exhibits potential to reduce treatment resistance and disease relapse in prostate cancer.

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