GDC-2992
Product Specifications
CAS Number
2753651-10-2
Synonyms
RO7656594
Target
Androgen Receptor
Applications
Endocrinology & Hormones
Molecular Formula
C45H51ClN8O5
Additionnal Information
GDC-2992 (RO7656594, Compound 28A) is an orally active degrader of androgen receptor (AR) with a DC50 of 2.7 nM. It binds to AR and cereblon (CRBN), inducing AR ubiquitination and degradation. GDC-2992 also inhibits cell proliferation in VCaP cells and exhibits potential to reduce treatment resistance and disease relapse in prostate cancer.
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