Z57346765 hydrochloride
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Z57346765 hydrochloride is an inhibitor of phosphoglycerate kinase 1 (PGK1) that binds to the ADP-binding pocket with a KD value of 2.09 x 10−5 M, reducing PGK1 metabolic enzyme activity, glucose consumption, and lactate production. It also inhibits DNA replication, impairs DNA damage repair, and induces cell cycle arrest in kidney renal clear cell carcinoma (KIRC) cells.
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