Isosilybin A

Isosilybin A is a flavonolignan isolated from silymarin that exhibits anti-prostate cancer (PCA) efficacy with an IC50 of 32 μM in DU145 cells. It induces growth inhibition, G1 arrest, and apoptosis in PCA cells by targeting the Akt-NF-κB-AR axis, highlighting its potential as a therapeutic agent in clinical prostate cancer (PCA) management.