Mitoguazone
Product Specifications
CAS Number
459-86-9
Synonyms
Methylglyoxal-bis (guanylhydrazone), MGBG, Methyl-GAG
Target
Apoptosis related
Applications
Apoptosis
Molecular Formula
C5H12N8
Additionnal Information
Mitoguazone (MGBG, Methyl-GAG) is a polyamine analog that disrupts polyamine biosynthesis by inhibiting S-adenosylmethionine decarboxylase (SAMDC) . It induces apoptosis and triggers p53-independent programmed cell death in the MCF7 cell line. It also inhibits the integration of HIV DNA into cellular DNA in both monocytes and macrophages.
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