Azimilide

Azimilide (NE-10064) is a class III antiarrhythmic compound, inhibits I (Ks) and I (Kr) in guinea-pig cardiac myocytes and I (Ks) (minK) channels expressed in Xenopus oocytes.IC50 value:Target: in vitro: Azimilide blocked HERG channels at 0.1 and 1 Hz with IC50s of 1.4 microM and 5.2 microM respectively. Azimilide blockade of HERG channels expressed in Xenopus oocytes and I (Kr) in mouse AT-1 cells was decreased under conditions of high [K+]e, whereas block of slowly activating I (Ks) channels was not affected by changes in [K+]e . Azimilide suppressed the following currents (Kd in parenthesis) : IKr (< 1 microM at -20 mV), IKs (1.8 microM at +30 mV), L-type Ca current (17.8 microM at +10 mV), and Na current (19 microM at -40 mV) . Azimilide was a