VH032
Product Specifications
CAS Number
1448188-62-2
Target
E3 Ligase
Applications
Ubiquitin
Molecular Formula
C24H32N4O4S
Additionnal Information
VH032 is a potent and selective VHL ligand used in PROTACs that binds to the VHL E3 ligase with a Kd of 185 nM and disrupts the VHL:HIF-α interaction. By stabilizing HIF-α, it activates the hypoxic response and serves as a tool for developing therapies targeting hypoxia signaling.
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