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Almorexant

Product Specifications

CAS Number

871224-64-5

Synonyms

ACT 078573

Additionnal Information

Almorexant (ACT 078573) is an orally active, potent and competitive dual orexin receptor antagonist, with Kd values of 1.3 nM (OX1) and 0.17 nM (OX2), respectively. Almorexant reversibly blocks signaling of orexin-A and orexin-B peptides. Almorexant totally blocked the intracellular Ca2+ signal pathway. Almorexant stimulates caspase-3 activity in AsPC-1 cells and induces apoptosis.

Storage Conditions

3 years-20°C powder 2 years-80°C in solvent

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