A-674563
Product Specifications
CAS Number
552325-73-2
Target
Akt
Applications
PI3K/Akt/mTOR
Molecular Formula
C22H22N4O
Additionnal Information
A-674563 is a selective, orally active inhibitor of Akt1 with a Ki of 11 nM. It also inhibits PKA with Ki of 16 nM and CDK2 with Ki of 46 nM. A-674563 reduces Akt downstream target phosphorylation and inhibits tumor cell proliferation in vitro with an EC50 of 0.4 μM.
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