Cuprizone

Cuprizone (biscyclohexanone oxalyldihydrazone) is a copper-chelating compound that forms stable, deep blue complexes with copper (II) ions, making it valuable for colorimetric assays to detect trace copper levels. It induces demyelination and schizophrenia-like behaviors in mice by interfering with copper-dependent enzymes, causing oxidative stress, and altering dopamine levels in critical brain regions.