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FMC-376

Product Specifications

CAS Number

2925468-57-9

Molecular Formula

C35H33F3N6O2 3533362

Additionnal Information

KRASG12C. It binds covalently to the mutant cysteine at position 12 in KRAS G12C and directly blocks both the ON and OFF conformations of the mutant KRAS protein, leading to a complete and durable blockade of downstream signaling. FMC‐376 exhibits robust anti‐tumor activity in vivo.G12C

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