USP5-IN-1
Product Specifications
CAS Number
2851040-81-6
Smiles
O=S (C1=CC=C (C (NCC (O) =O) =O) N=C1) (N2CCC (C3=CC=C (Cl) C=C3) CC2) =O
Molecular Formula
C19H20ClN3O5S
Additionnal Information
USP5-IN-1 (compound 64) is a selective competitive inhibitor of USP5 zinc finger ubiquitin binding domain (ZnF-UBD) with a Kd of 2.8 μM. It competitively blocks ubiquitin binding to the ZnF-UBD domain, suppressing USP5 catalytic activity and ubiquitin chain hydrolysis, with potential applications as a chemical probe and therapeutic agent in USP5-related cancers.
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