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2BAct

Product Specifications

CAS Number

2143542-28-1

Smiles

O=C (C (C=N1) =NC=C1C (F) F) NC (C2) (C3) CC23NC (COC (C=C4) =CC (F) =C4Cl) =O

Molecular Formula

C19H16ClF3N4O3

Additionnal Information

2BAct is a potent, orally bioavailable eIF2B activator exhibiting high selectivity (EC50 = 33 nM) . It mitigates neurological impairments induced by persistent integrated stress response. The compound demonstrates blood-brain barrier penetration with enhanced solubility and pharmacokinetic properties compared to ISRIB trans-isomer .

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