1-Naphthohydroxamic acid

Product Specifications

CAS Number

6953-61-3

Target

HDAC

Applications

DNA Damage/DNA Repair

Smiles

O=C (C1=C2C=CC=CC2=CC=C1) NO

Molecular Formula

C11H9NO2

Additionnal Information

1-Naphthohydroxamic acid (Compound 2) demonstrates potent and selective inhibition of HDAC8 (IC50 = 14 μM), exhibiting significantly greater selectivity for HDAC8 compared to class I HDAC1 and class II HDAC6 (IC50 >100 μM) . This compound does not elevate global histone H4 acetylation levels nor decrease total intracellular HDAC activity. Additionally, 1-naphthohydroxamic acid has been shown to promote tubulin acetylation.