1-Naphthohydroxamic acid
Product Specifications
CAS Number
6953-61-3
Target
HDAC
Applications
DNA Damage/DNA Repair
Smiles
O=C (C1=C2C=CC=CC2=CC=C1) NO
Molecular Formula
C11H9NO2
Additionnal Information
1-Naphthohydroxamic acid (Compound 2) demonstrates potent and selective inhibition of HDAC8 (IC50 = 14 μM), exhibiting significantly greater selectivity for HDAC8 compared to class I HDAC1 and class II HDAC6 (IC50 >100 μM) . This compound does not elevate global histone H4 acetylation levels nor decrease total intracellular HDAC activity. Additionally, 1-naphthohydroxamic acid has been shown to promote tubulin acetylation.
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
MBS6299799-01 0.2 mL
FOXI1, ID (FOXI1, FKHL10, FREAC6, Forkhead box protein I1, Forkhead-related protein FKHL10, Forkhead-related transcription factor 6, Hepatocyte nuclear factor 3 forkhead homolog 3) (Azide free) (HRP)
Sign In for Pricing
View Details MBS6299799-02 5x 0.2 mL
FOXI1, ID (FOXI1, FKHL10, FREAC6, Forkhead box protein I1, Forkhead-related protein FKHL10, Forkhead-related transcription factor 6, Hepatocyte nuclear factor 3 forkhead homolog 3) (Azide free) (HRP)
Sign In for Pricing
View Details