1-Naphthohydroxamic acid
Product Specifications
CAS Number
6953-61-3
Target
HDAC
Applications
DNA Damage/DNA Repair
Smiles
O=C (C1=C2C=CC=CC2=CC=C1) NO
Molecular Formula
C11H9NO2
Additionnal Information
1-Naphthohydroxamic acid (Compound 2) demonstrates potent and selective inhibition of HDAC8 (IC50 = 14 μM), exhibiting significantly greater selectivity for HDAC8 compared to class I HDAC1 and class II HDAC6 (IC50 >100 μM) . This compound does not elevate global histone H4 acetylation levels nor decrease total intracellular HDAC activity. Additionally, 1-naphthohydroxamic acid has been shown to promote tubulin acetylation.
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