PolQi2

Product Specifications

CAS Number

2565638-16-4

Target

DNA/RNA Synthesis

Applications

Cell Cycle

Smiles

O=C (C1=CC=NC=C1C2=C (OC) C=CC=C2) NC3=NN=C (S3) OCC4=NC=C (C=C4) Cl

Molecular Formula

C21H16ClN5O3S

Additionnal Information

PolQi2 is a PolΘ inhibitor that specifically targets the N-terminal helicase domain of PolΘ, thereby suppressing alt-EJ (alternative end-joining) repair. This compound improves the accuracy and integration efficiency of gene editing across multiple loci and diverse cell lines. Additionally, PolQi2 demonstrates synergistic effects with DNA-PK inhibitors in reducing Cas9-mediated off-target activity. Its application is suitable for gene editing studies.