PolQi2
Product Specifications
CAS Number
2565638-16-4
Target
DNA/RNA Synthesis
Applications
Cell Cycle
Smiles
O=C (C1=CC=NC=C1C2=C (OC) C=CC=C2) NC3=NN=C (S3) OCC4=NC=C (C=C4) Cl
Molecular Formula
C21H16ClN5O3S
Additionnal Information
PolQi2 is a PolΘ inhibitor that specifically targets the N-terminal helicase domain of PolΘ, thereby suppressing alt-EJ (alternative end-joining) repair. This compound improves the accuracy and integration efficiency of gene editing across multiple loci and diverse cell lines. Additionally, PolQi2 demonstrates synergistic effects with DNA-PK inhibitors in reducing Cas9-mediated off-target activity. Its application is suitable for gene editing studies.
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