Safusidenib
Product Specifications
CAS Number
1898206-17-1
Synonyms
AB-291; DS-1001
Smiles
O=C (N1C2=CC=CC (/C=C/C (O) =O) =C2C (C) =C1) C3=C (C (C) (F) C) ON=C3C4=C (C=C (C=C4Cl) Cl) Cl
Molecular Formula
C25H18Cl3FN2O4
Additionnal Information
Safusidenib (AB-291; DS-1001) is an orally bioavailable, selective inhibitor of mutant IDH1. It demonstrates potent inhibition against mutant IDH1 while showing minimal activity against the wild-type enzyme. The compound exhibits antitumor effects in chondrosarcoma models. In vitro assays without preincubation, safusidenib inhibits IDH1R132H and IDH1R132C with IC50 values of 15 nM and 130 nM, respectively.
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