E1231
Product Specifications
CAS Number
1031195-19-3
Synonyms
1-{4-[2- (5-Methylfuran-2-yl) quinoline-4-carbonyl]piperazin-1-yl}ethan-1-one
Target
Survivin
Applications
Apoptosis
Molecular Formula
C21H21N3O3
Additionnal Information
E1231 (1-{4-[2- (5-Methylfuran-2-yl) quinoline-4-carbonyl]piperazin-1-yl}ethan-1-one) is a piperazine 1,4-diamide compound and an oral activator of SIRT1 with an EC50 of 0.83μM. It increases cholesterol efflux and decreases lipid accumulation in macrophages. E1231 regulates cholesterol and lipid metabolism in hyperlipidemic golden hamsters, with potential for atherosclerosis treatment.
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