Tetrabenazine
Product Specifications
CAS Number
718635-93-9
Synonyms
Ro 1-9569
Target
VMAT
Applications
Transmembrane Transporters
Molecular Formula
C19H27NO3
Additionnal Information
Tetrabenazine (Ro 1-9569) is a non-competitive inhibitor of the vesicular monoamine transporter (VMAT), with a higher selectivity for VMAT2 over VMAT1. It exhibits an IC50 of 0.3 μM for VMAT2 and 3 μM for VMAT1, and a Kd of 60 nM for VMAT2 and 9.38 nM for VMAT1. It treats Huntington’s chorea by reducing excessive dopaminergic activity and impairing monoamine storage in synaptic vesicles.
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
TA592582 100 µL
mIgG2a Fcγ Fragment Specific Rabbit monoclonal antibody,clone OTIR9D3
Sign In for Pricing
View Details 
![NCOA1 Rabbit Monoclonal Antibody [Clone ID: R07-5B7]](https://cdn.genprice.uk/products/937/6868c2ff994c49e6dc3ec19a/imageurl/ta421965.webp)
TA421965 100 µL
NCOA1 Rabbit Monoclonal Antibody [Clone ID: R07-5B7]
Sign In for Pricing
View Details