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VLS-1272

Product Specifications

CAS Number

2914878-00-3

Target

Kinesin

Applications

Cytoskeletal Signaling

Molecular Formula

C27H35N3O5S2

Additionnal Information

VLS-1272 is an orally bioavailable, potent, ATP non-competitive, microtubule-dependent, and highly selective inhibitor of KIF18A with an IC50 of 41 nM. It induces mitotic defects with strong anti-mitotic, anti-cancer, and anti-proliferative effects, leading to dose-dependent tumor growth inhibition and can be used for the study of cancers with high chromosomal instability.

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