PZL-A
Product Specifications
CAS Number
3068830-89-4
Target
DNA/RNA Synthesis
Applications
Cell Cycle
Molecular Formula
C19H17ClN4O2
Additionnal Information
PZL-A is a activator of mitochondrial DNA (mtDNA) synthesis. PZL-A restores wild-type-like activity to mutant forms of polymerase γ (POLγ) with 160 nM for A467T and 20 nM for G848S. In cellular systems, PZL-A stimulates mtDNA synthesis, promoting oxidative phosphorylation complex biogenesis and improving cellular respiration. PZL-A is promising agent for relieving POLG disease and other severe conditions linked to depletion of mtDNA.
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