PF-07853578

PF-07853578 (Example 11) is a degrader of Patatin-Like Phospholipase Domain-Containing Protein 3 (PNPLA3) with an EC50 of 5.2 nM. It may be useful for the treatment and prevention of liver diseases, including fatty liver, nonalcoholic fatty liver disease (NALFD), nonalcoholic steatohepatitis (NASH), liver fibrosis, cirrhosis, and hepatocellular carcinoma.