FEN1-IN-1
Product Specifications
CAS Number
824983-91-7
Target
FENs
Applications
DNA Damage/DNA Repair
Molecular Formula
C15H12N2O5S
Additionnal Information
FEN1-IN-1 (Compound 1) is an inhibitor of Flap endonuclease 1 (FEN1), binding to its active site and inhibiting activity partly by coordinating with Mg2+ ions. By blocking FEN1, it initiates a DNA damage response, activating the ATM checkpoint pathway, histone H2AX phosphorylation, and FANCD2 ubiquitination in mammalian cells.
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