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VAV1 degrader-3

Product Specifications

CAS Number

3050683-38-7

Synonyms

MRT-6160

Molecular Formula

C22H17ClN2O3

Additionnal Information

VAV1 degrader-3 (MRT-6160) is an orally active molecular glue degrader of VAV1 with a DC50 of 7 nM. It suppresses immune activation, proliferation, and cytokine production, inhibiting disease progression in inflammatory and autoimmune models like encephalomyelitis (EAE) and Collagen-induced arthritis (CIA) .

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