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OICR-8268

Product Specifications

CAS Number

3000549-26-5

Target

E3 Ligase

Applications

Ubiquitin

Molecular Formula

C19H14Cl2F2N4O2

Additionnal Information

OICR-8268 is a potent, reversible and in-cell active DCAF1 ligand. It significantly binds to DCAF1 WDR domain with an Kd value of 38 nM. It serves as a promising starting point for developing chemical handles for DCAF1-based PROTACs targeting selective protein degradation as well as cancer therapeutics.

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