BBI-2779
Product Specifications
CAS Number
2871057-47-3
Target
Chk
Applications
Cell Cycle
Smiles
COC1=CC=CC (O[C@H]2[C@@H] (CC2) N) =C1C3=CC (NC4=NC=C (C#N) N=C4) =NN3
Molecular Formula
C19H19N7O2
Additionnal Information
BBI-2779 is a potent, selective, and orally active inhibitor of CHK1 with an IC50 of 0.3 nM. It preferentially kills cancer cells containing extrachromosomal DNA (ecDNA) by inducing replication stress and cell death. In gastric cancer models with FGFR2 gene amplification on ecDNA, BBI-2779 suppresses tumor growth and prevents drug resistance.
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