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PU139

Product Specifications

CAS Number

158093-65-3

Target

Histone Acetyltransferase

Applications

Epigenetics

Molecular Formula

C12H7FN2OS

Additionnal Information

PU139 is a potent inhibitor of pan-histone acetyltransferase (HAT) that blocks Gcn5, PCAF, CBP, and p300 with IC50 values of 8.39 μM, 9.74 μM, 2.49 μM, and 5.35 μM, respectively. It significantly impairs Smp14 promoter activity, suggesting that targeting SmGCN5 and SmCBP1 is a novel strategy to control S. mansoni egg development, it also exhibits anticancer activity.

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